And I'm not going to take on a paper to review unless I have the time. Fahy made are based on a massive misunderstanding of the proposal.
It seems plausible, therefore, that with continued advances in cryobiology the need for sophisticated repair methods can be avoided entirely.
After I have finished reading the manuscript, I let it sink in for a day or so and then I try to decide which aspects really matter.
When you deliver criticism, your comments should be honest but always respectful and accompanied with suggestions to improve the manuscript.
He does this by multiplying the in Critique darticle scientifique synthesis time by 10 to account for the fact that not only molecular synthesis but also computations about such synthesis will be needed.
The human brain has roughly nerve cells, plus perhaps ten times as many glial cells and other support cells. How can energy be translated from the macroscopic to the molecular level?
The problems that remain are fundamental and are not obscured by a cloud of secondary issues. Merkle The October, vol.
Note that with intact membranes, diffusion outside of well defined compartments will not take place. Thus, some repairs made below Tg could induce the need for more repairs!
Femtoseconds and picoseconds are the units typically used. It is therefore quite obviously inappropriate to assume that normal biological repair processes provide anything comparable to a "proof of principle" that repair can be effected below Tg.
If there is a major flaw or concern, I try to be honest and back it up with evidence. I usually write down all the things that I noticed, good and bad, so my decision does not influence the content and length of my review. Changes in Tissue Volume: The second class of methods seek to build an actual human brain, on the grounds that we have a high degree of confidence that a human brain can support consciousness and human thought.
The appendix to reference  says: I'm critiquing the work, not the authors.
This might be called "minimal stabilization. Conclusions that are overstated or out of sync with the findings will adversely impact my review and recommendations. Enzymes take advantage of thermal energy that is already available within the reacting species to supply the activation energy required for chemistry the making or breaking of covalent bonds to occur.
Unfortunately for this argument, extremely rapid warming does not impart momentum per se, and volume changes caused by temperature changes can be compensated by a number of mechanisms e. Occasionally, there are difficulties with a potentially publishable article that I think I can't properly assess in half a day, in which case I will return the paper to the journal with an explanation and a suggestion for an expert who might be closer to that aspect of the research.
So now, I only sign my reviews so as to be fully transparent on the rare occasions when I suggest that the authors cite papers of mine, which I only do when my work will remedy factual errors or correct the claim that something has never been addressed before. Fahy has argued that building a brain at low temperature and then warming it is "nonsensical" because inter alia it would explode.
I also think it is our duty as researchers to write good reviews. Since obtaining tenure, I always sign my reviews. A sufficiently accurate digitization for any purpose considered here would be provided by giving the coordinates and orientation of every major molecule in the brain; 2 Once a complete description of the frozen structure is available in digital format, the description can be manipulated and revised to eliminate the damage; 3 Once we have a digital description of a healthy human brain, we can then use that description as a blueprint to rebuild the original.
The final concern is how to build a structure with atomic precision, given the blueprint. Some General Approaches to Repair Before addressing the specific issues surrounding low temperature synthesis, it would be advisable to discuss the general issues involved in synthesis at any temperature, and the kinds of structures that might prove satisfactory.II — Les principes de la communication médicale scientifique.
III — La structure du rapport d'une étude. IV — Les principes de la lecture critique. V — La lecture critique Pages: L’enseignement de la lecture critique doit donc se faire par des méthodologistes et des cliniciens.
Leur coordination avec un enseignant en anglais scientifique semble être une bonne solution pour faire comprendre aux étudiants l’intérêt d’une analyse critique . Nov 17, · Les principaux critères à retenir pour l'identification d'un article de revue scientifique sont présentés dans cette vidéo.
Nov 17, · Les principaux critères à retenir pour l'identification d'un article de revue scientifique sont présentés dans cette vidéo.
La culture scientifique et l’esprit critique sont essentiels pour permettre aux futurs citoyens de penser par eux-mêmes. Dec 13, · Lecture Critique d'Article médical 13/12/ Urgences Agen.Download